NCT06907667

Study of the Impact of Time of Vaccination on Response to Influenza Vaccine in Patients With Chronic Renal Failure

Study of the Impact of Time of Vaccination on Response to Influenza Vaccine in Patients With Chronic Renal Failure - CHRONOVAX 2

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 735 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Nice · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

Immune response to influenza vaccine in patients with chronic renal insufficiency.

Detailed description

Seasonal influenza vaccination is recommended for patients with chronic renal insufficiency, as influenza is responsible for significant morbidity and mortality in this immunocompromised population. However, the immune response to this vaccination is limited in this population. There are currently no recommendations concerning the timing of influenza vaccine in the general population or in immunocompromised patients. In this context, recent studies have shown that the time of vaccination can have an impact on vaccine efficacy. This is the case for BCG, influenza and COVID vaccinations. On this basis, our main hypothesis is that the administration of influenza vaccine to patients with chronic kidney failure is more effective in the morning than in the evening.

Conditions

• Vaccination; Infection

Interventions

Type	Name	Description
OTHER	Vaccine injection	Injection of the vaccine in chronic renal insufficiency patients.

Timeline

• Start date: 2025-09-03
• Primary completion: 2026-03-01
• Completion: 2026-09-01
• First posted: 2025-04-02
• Last updated: 2025-09-11

Locations

1 site across 1 country: France