NCT06907095

Cohort Evaluation of Body Fluids Early Detection of Cancer in High-risk Individuals

A Prospective Cohort to Evaluate the Ability of Different Body fLuid-derived Approaches to Detect EArly-stage Cancers Among High-risk Individuals

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 5,909 (estimated)
• Sponsor: Gustave Roussy, Cancer Campus, Grand Paris · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

LEAH is a prospective, observational, single-centre, non-randomised, open-label study of people at increased risk of cancer or malignant disease. The main objective of LEAH is to evaluate and compare the sensitivity of different tests on body fluids to detect cancers that will occur within 3 years of inclusion in the study, in a cohort of individuals identified as being at increased risk of cancer.

Conditions

• Risk of Breast Cancer
• Risk of Gynaecological Cancer
• Risk of Colorectal Cancer
• Risk of Upper Gastrointestinal Cancers
• Risk of Hepatic Cancers
• Risk of Lung Cancer
• Risk of Skin Cancers Except Basal-cell Carcinomas
• Risk of Head and Neck Cancers
• Risk of Mesothelioma
• Risk of Kidney Cancer
• Risk of Prostate Cancer
• Risk of Urothelial Cancers
• Risk of Endocrine Cancers
• Risk of Hematologic Malignancies
• Risk of Several Cancer Types
• Risk of Second Malignancy in Individuals Treated for a Childhood Cancer
• Risk of Neoplasia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	biological samples	biological samples (blood, urine, saliva)

Timeline

• Start date: 2026-03-16
• Primary completion: 2030-06-01
• Completion: 2030-06-01
• First posted: 2025-04-02
• Last updated: 2026-03-30

Locations

1 site across 1 country: France