NCT06906536

Examining the Effect of Acute Intermittent Hypoxia on Serum Blood Proteins and Lower Limb Function

Examining the Effect of Acute Intermittent Hypoxia on Serum Blood Proteins, Corticospinal Excitability, and Force Control in Persons With Incomplete Spinal Cord Injury

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University of Colorado, Boulder · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to clarify mechanisms of acute intermittent hypoxia and to examine the effect on lower limb function in persons with chronic, incomplete spinal cord injury.

Detailed description

The goal of this study is to clarify mechanisms of acute intermittent hypoxia by examining changes in blood biomarkers, neural excitability, and hemoglobin mass. We also aim to clarify how these changes relate to changes in lower limb function in persons with chronic, incomplete spinal cord injury by measuring force steadiness and voluntary muscle activation.

Conditions

• INCOMPLETE SPINAL CORD INJURY (ASIA D)
• Able Bodied

Interventions

Type	Name	Description
OTHER	Acute Intermittent Hypoxia (AIH)	4 consecutive days of 15, 1.5 min episodes at 9% O2 (AIH) alternating with 21% O2 at 1 min intervals

Timeline

• Start date: 2024-03-01
• Primary completion: 2026-03-01
• Completion: 2026-08-01
• First posted: 2025-04-02
• Last updated: 2025-04-04

Locations

1 site across 1 country: United States