NCT06903806

Microbiome Sampling During Endurance Exercise

Determination of Microbiome Diversity and Inflammation Throughout the GI Tract During Endurance Exercise

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The small intestine and feces of subjects undergoing endurance exercise will be sampled to examine their microbiome composition

Detailed description

The close relationship between humans and the commensal microbes of their gut microbiota represents vast potential for health maintenance, but most efforts have been focused on disease. Gastrointestinal (GI) problems are very common especially in endurance athletes, and are known to impair performance or subsequent recovery. Moreover, GI symptoms among athletes vary enormously, and some athletes are more prone than others; the links between this variation and the differences in microbiome composition across individuals have not been elucidated. The investigators propose to use a novel, non-invasive sampling technology to quantify the effects of exercise on the GI environment including the small intestines, and aim to establish the potential for dietary interventions to improve recovery from exercise.

Conditions

• Healthy
• Exercise-Induced Lactic Acidemia

Interventions

Type	Name	Description
OTHER	Treadmill Exercise	Participants perform moderate to strenuous exercise for up to 20 minutes on a treadmill after swallowing a microbiome sampling capsule.
DEVICE	Cooling Gloves	Cooling gloves to prevent rise in core body temperature during exercise
DEVICE	Microbiome Capsule	Capsule used for collecting intestinal tract contents

Timeline

• Start date: 2024-08-04
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2025-04-01
• Last updated: 2025-04-01

Locations

1 site across 1 country: United States