NCT06903546

The Effect of Propolis Administration on Cholesterol Level in Diabetic Type 2 Patients

The Effect of Propolis Administration on Low Density Lipoprotein and High Density Lipoprotein in Diabetic Type 2 Patients in Central Jakarta

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 64 (estimated)
• Sponsor: Indonesia University · Academic / Other
• Sex: All
• Age: 35 Years – 59 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn if propolis administration works to change the level of Low Density Lipoprotein (LDL) and High Density Lipoprotein cholesterol (HDL) in diabetic type 2 patients. The main questions it aims to answer are: \- Is giving 1 drops/ 10kg/ times, twice daily for 8 weeks will change the level of LDL and HDL level in diabetic type 2 patients compared to placebo? Researchers will compare propolis to a placebo (a look-alike substance that contains no drug) to see if propolis works to change LDL and HDL cholesterol level. Participants will: * Take propolis or a placebo, 2 times daily with given dose (1 drops/10 kg/times) every day for 2 months * Visit the sub-district health centre once every 2 weeks for checkups * Get their blood checked before and after intervention

Detailed description

Subject allocation into groups will be made by third party to ensure masking/ blinding protocol. Data that will be taken from participants : * Private information * Medication history (for type 2 Diabetes Mellitus) * Food intake (calories, fats, carbohydrate, protein, and flavonoid intake) * Physical activity status

Conditions

• Diabetes Mellitus Type 2

Interventions

Type	Name	Description
DRUG	Propolis drops	The intervention given is propolis drops that are approved by Indonesian Food and Drug Authority
OTHER	Placebo	The given placebo are look-alike substance with no effect

Timeline

• Start date: 2025-03-18
• Primary completion: 2025-06-30
• Completion: 2025-07-31
• First posted: 2025-03-30
• Last updated: 2025-04-03

Locations

1 site across 1 country: Indonesia