NCT06902831

Comparative Outcomes of Endoscopic and Open Carpal Tunnel Release with Neurotrophic Supplementation in Severe Carpal Tunnel Syndrome

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 497 (actual)
• Sponsor: University of Bari · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study addresses the pressing clinical question of optimizing surgical and pharmacological interventions for severe Carpal Tunnel Syndrome (CTS), a prevalent and debilitating condition caused by median nerve compression. Previous research has established the efficacy of Open Carpal Tunnel Release (OCTR) and Endoscopic Carpal Tunnel Release (ECTR); however, the role of neurotrophic supplementation in enhancing surgical outcomes has yet to be fully elucidated. Using a prospective clinical approach involving 497 patients, we evaluated the comparative outcomes of ECTR and OCTR with or without neurotrophic supplementation. Key findings demonstrate that ECTR, particularly when combined with neurotrophic agents, facilitates faster recovery and greater improvements in Sensory Nerve Conduction Velocity (VCS) and Visual Analog Scale (VAS) scores, with reduced complication rates compared to OCTR

Conditions

• Carpal Tunnel Syndrome (CTS)

Interventions

Type	Name	Description
PROCEDURE	Endoscopic Carpal Tunnel Release	Release of carpal tunnel with endoscopic device
PROCEDURE	Open carpal tunnel release	Release of carpal tunnel with open tecnique
DRUG	Neurotrophic supplementation	Neurotrophic supplementation after surgery

Timeline

• Start date: 2022-06-01
• Primary completion: 2024-04-01
• Completion: 2024-04-01
• First posted: 2025-03-30
• Last updated: 2025-03-30

Locations

1 site across 1 country: Italy