NCT06901271

Pharmacological and Nonpharmacological Methods for Children in Venipuncture Pain

The Effect of EMLA Cream, Cold Spray, and Buzzy on Venipuncture Pain and Fear in Children: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 192 (actual)
• Sponsor: Aynur Aytekin Ozdemir · Academic / Other
• Sex: All
• Age: 7 Years – 12 Years
• Healthy volunteers: Accepted

Summary

This study aimed to examine the effect of EMLA cream, cold spray, and Buzzy applied during venipuncture on the pain and fear levels of children aged 7-12 years.

Detailed description

The International Guide to Pediatric Anesthesia (Good Practice in Postoperative and Procedural Pain) recommends pharmacological and nonpharmacological methods to effectively manage and prevent acute procedural pain in children. Nonpharmacological methods alone or in combination with pharmacological methods help reduce pain, and therefore, have become popular especially in recent years. For pain management, nonpharmacological methods are easy to use, and cost- and time-effective methods with no side effects. Studies have evaluated a large number of pharmacological and nonpharmacological interventions for procedural pain management in children. However, most of those interventions are not used by healthcare professionals because they are expensive, time-consuming or hard to use. Therefore, easy-to-use, practical, non-invasive, cost-effective, and reusable pharmacological and nonpharmacological methods can be used especially in acute settings. EMLA cream, cold spray, and Buzzy examined in this study may serve as alternative effective pharmacological and non-pharmacological methods to reduce venipuncture pain and fear.

Conditions

• Procedural Pain Relief
• Fear Pain

Interventions

Type	Name	Description
DRUG	EMLA Cream	EMLA cream (2.5 grams) was applied to the treatment area 60 minutes before the procedure and covered with a transparent and impermeable dressing.
DEVICE	Buzzy	The buzzy device was placed on the procedure area 60 seconds before the procedure and turned on. The cold and vibration application continued during the procedure.
DRUG	Cold spray	Cold spray was applied to the procedure area for 5 seconds from a distance of 15 cm immediately before the procedure.

Timeline

• Start date: 2018-03-29
• Primary completion: 2019-06-28
• Completion: 2019-06-28
• First posted: 2025-03-28
• Last updated: 2025-03-28

Locations

1 site across 1 country: Turkey (Türkiye)