NCT06899321

The Effect of Cosmetic Products on Skin Brightening

A Clinical Study to Evaluate Test Products for Skin Brightening Benefit Under Controlled UV Exposure, in a 6-week Study Design

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 34 (estimated)
• Sponsor: Unilever R&D · Industry
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This is a single centre, single cell, blinded study designed to evaluate the effect of 5 cosmetic products on skin brightening, skin hydration and skin barrier function of the volar forearm after controlled UV exposure as compared to baseline and a no-treatment control.

Detailed description

This is a single centre, single cell, blinded study designed to evaluate the effect of cosmetic products on skin brightening, skin hydration and skin barrier function of the volar forearm after controlled UV exposure. This study will accept 34 participants who meet the inclusion and exclusion criteria. Participants will test all 5 products and a no-treatment control, which will be applied twice daily for 6 weeks to pre-defined test sites on their volar forearms. UV exposure will be conducted using a SOL UV solar simulator (300 - 1200nm; dose level 6 joules/cm2) at various time points during weeks 2 - 5 of the study. Instrumental assessments of skin brightening, skin hydration and skin barrier function will be conducted at regular intervals throughout the whole study. Non-invasive samples of the stratum corneum will be collected at several timepoints during the study to evaluate biomarkers of skin brightening.

Conditions

• Skin Brightening

Interventions

Type	Name	Description
OTHER	Cosmetic product M68	Cosmetic skin brightening product to be applied to defined test site
OTHER	Cosmetic product Z15	Cosmetic skin brightening product to be applied to defined test site
OTHER	Cosmetic product R52	Cosmetic skin brightening product to be applied to defined test site
OTHER	Cosmetic product J61	Cosmetic skin brightening product to be applied to defined test site
OTHER	Cosmetic product U36	Cosmetic skin brightening product to be applied to defined test site

Timeline

• Start date: 2025-03-01
• Primary completion: 2025-05-01
• Completion: 2025-05-01
• First posted: 2025-03-27
• Last updated: 2025-03-27

Locations

1 site across 1 country: India