Trials / Completed

CompletedNCT06898112

Mixed-methods Protocol for the WiSSPr Study

Mixed-methods Protocol for the WiSSPr Study: Women in Sex Work, Stigma and Psychosocial Barriers to Pre-exposure Prophylaxis in Zambia

Status: Completed
Phase: —
Study type: Observational
Enrollment: 299 (actual)

Sponsor: Centre for Infectious Disease Research in Zambia · Academic / Other
Sex: Female
Age: 18 Years
Healthy volunteers: Accepted

Summary

Detailed description

WiSSPr is a prospective observational cohort study grounded in community-based participatory research principles with a community advisory board (CAB) of key population (KP) civil society organi sations (KP-CSOs) and the Ministry of Health (MoH). We will administer a one-time psychosocial survey vetted by the CAB and follow 300 WESW in the electronic medical record for three months to measure PrEP initiation (#/% ever taking PrEP) and persistence (immediate discontinuation and a medication possession ratio). We will conduct in-depth interviews with a purposive sample of 18 women, including 12 WESW and 6 peer navigators who support routine HIV screening and PrEP delivery, in two community hubs serving KPs since October 2021. We seek to value KP communities as equal contributors to the knowledge production process by actively engaging KP-CSOs throughout the research process. Expected outcomes include quantitative measures of PrEP initiation and persistence among WESW, and qualitative insights into the enablers and barriers to PrEP use informed by participants' lived experiences. https://doi.org/10.1136/bmjopen-2023-080218

Conditions

PrEP Uptake

Interventions

Type	Name	Description
DRUG	PrEP	oral PrEP

Timeline

Start date: 2023-07-18
Primary completion: 2024-03-31
Completion: 2024-03-31
First posted: 2025-03-27
Last updated: 2025-03-27

Locations

1 site across 1 country: Zambia

Source: ClinicalTrials.gov record NCT06898112. Inclusion in this directory is not an endorsement.