NCT06896617

Impact of the Presence of the Corpus Luteum on Pregnancies Obtained Through Frozen Embryo Transfer(FET)

Impact of the Presence of the Corpus Luteum on Pregnancies Obtained Through Frozen Embryo Transfer(FET): a Prospective Randomized Controlled Study

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 334 (estimated)
• Sponsor: Fundacion Clinic per a la Recerca Biomédica · Academic / Other
• Sex: Female
• Age: 18 Years – 41 Years
• Healthy volunteers: Accepted

Summary

In pregnancies achieved through programmed frozen embryo transfer cycle (PC-FET) and modified natural frozen embryo transfer (mNC-FET), to determine whether there are differences in endothelial and placental function, maternal cardiovascular function, fetal growth and fetal cardiovascular and cerebral programming and to assess whether there is an association between these differences and the plasma concentrations of the main secretion products of the Corpus Luteum (CL) with vasoactive and angiogenic action.

Conditions

• Infertilities
• Embryo Transfer

Interventions

Type	Name	Description
DRUG	Estradiol + Progesterone	Pregnancies with absence of corpus luteum(PC-FET)
DRUG	Ovitrelle ( Hcg 250 mcg)	NC-FET(natural cycle FET, endometrial preparation with presence of CL)

Timeline

• Start date: 2025-02-01
• Primary completion: 2026-11-20
• Completion: 2026-12-20
• First posted: 2025-03-26
• Last updated: 2025-04-02

Locations

1 site across 1 country: Spain