NCT06896370

An Observational Study for Gastric Cancer in Carriers of High Risk Helicobacter Pylori

Risk of Gastric Cancer in High-risk Carriers of Helicobacter Pylori: an Observational Cohort Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 3,000 (estimated)
• Sponsor: Fudan University · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

This study is intended to be a prospective observational cohort study. The incidence of gastric cancer and progression of gastric precancerous lesions will be compared between groups through prospective follow-up of a population with baseline negative gastric endoscopy, harboring high-risk Hp SNP subtypes and non-high-risk subtypes.

Detailed description

Primary study objective: to assess the difference in the incidence of gastric cancer between carriers of high-risk SNP subtypes of H. pylori and the non-high-risk population during the follow-up period. Secondary research objectives: 1. To observe and compare the cumulative incidence and progression of gastric precancerous lesions (e.g., atrophic gastritis, intestinal metaplasia, etc.) in each population group during the follow-up period.2. To explore the interaction of high-risk SNPs on the risk of gastric cancer in the context of different age, gender or other risk factors (e.g. diet, smoking, alcohol abuse, family history, etc.).

Conditions

• Gastric (Stomach) Cancer
• Helicobacter Infection

Interventions

Type	Name	Description
OTHER	observational study	By prospectively following a population of asymptomatic carriers carrying high-risk Hp SNP subtypes and non-high-risk subtypes, the incidence of gastric cancer and progression of gastric precancerous lesions were compared between the groups.

Timeline

• Start date: 2025-07-01
• Primary completion: 2035-05-01
• Completion: 2035-12-31
• First posted: 2025-03-26
• Last updated: 2026-02-25

Locations

1 site across 1 country: China