NCT06894433

Efficacy and Safety of NeuroEndoscopic Surgery for Large IntraCerebral Hemorrhage

Efficacy and Safety of NeuroEndoscopic Surgery for Large IntraCerebral Hemorrhage: a Multicenter, Randomized, Controlled Clinical Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 280 (estimated)
• Sponsor: Southwest Hospital, China · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This is a multicenter, randomized, controlled clinical trial comparing neuroendoscopic hematoma removal to craniotomy in the treatment of large intracerebral hemorrhage.

Detailed description

Previous retrospective studies have demonstrated that neuroendoscopic surgery, compared to conventional craniotomy, significantly reduces operative duration and intraoperative blood loss, enhances hematoma evacuation rates, and improves postoperative outcomes, including neurological recovery, activities of daily living, and quality of life in patients with large cerebral hemorrhage. However, there is a paucity of prospective randomized controlled trials evaluating the efficacy of different surgical techniques for intracerebral hemorrhage. To address this gap, the investigators propose a multicenter, randomized, controlled clinical trial to compare the safety and efficacy of neuroendoscopic surgery versus craniotomy, aiming to provide evidence-based guidance for surgical decision-making in cerebral hemorrhage management.

Conditions

• Intracerebral Haemorrhage

Interventions

Type	Name	Description
PROCEDURE	neuroendoscopic surgery	Subjects will receive Neuroendoscopic Surgery followed by standard medical management
PROCEDURE	craniotomy	Subjects will receive Craniotomy followed by standard medical management

Timeline

• Start date: 2025-06-01
• Primary completion: 2028-06-30
• Completion: 2028-12-31
• First posted: 2025-03-25
• Last updated: 2025-05-18

Locations

2 sites across 1 country: China