NCT06894069

Intracanal Dexamethasone Extrusion and Postoperative Endodontic Pain

Effect of Intentional Extrusion of an Intracanal Corticosteroid Solution on Post Endodontic Treatment Pain: a Randomized Clinical Trial

• Status: Not Yet Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: University of Jordan · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The aim of this research is to assess the effect of intentionally extruding a corticosteroid intracanal solution into the periapical tissues on the postoperative pain after root canal treatment in patients with symptomatic irreversible pulpitis and symptomatic apical periodontitis (SIP/SAP). The main question it aims to answer: Is there an analgesic effect of extruding an intracanal solution of DXA into the periapical tissues in patients diagnosed with SIP/SAP? Researchers will compare dexamethasone to a placebo to see if the extrusion dexamethasone works in reducing post-endodontic treatment pain.

Conditions

• Post Operative Pain Control
• Endodontic Treatment

Interventions

Type	Name	Description
DRUG	Dexamethasone	a 2 ml solution of dexamethasone (3.3mg/ml) will be flushed in the root canal and intentionally extruded to the periradicular tissues to assess its potnetial sedative effect
OTHER	Placebo	2ml of normal saline will be used as placebo to be flushed and extruded through the canals to the periradicular tissues

Timeline

• Start date: 2025-03-01
• Primary completion: 2025-05-01
• Completion: 2025-05-01
• First posted: 2025-03-25
• Last updated: 2025-03-26