NCT06889584

Supplement Combination on Stress and Sleep

Evaluating the Efficacy of a Supplement Combination for Improving Stress and Sleep: A Randomized Placebo-Controlled Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 115 (actual)
• Sponsor: University of South Carolina · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this clinical trial is to assess the effects of a supplement combination on measures of sleep quality and stress in healthy adults.

Conditions

• Healthy

Interventions

Type	Name	Description
COMBINATION_PRODUCT	All Active Supplement Combinations (Ashwagandha, Rhodiola rosea, magnesium threonate, L-theanine, and apigenin))	Ashwagandha, Rhodiola rosea, magnesium threonate, L-theanine, and apigenin.
COMBINATION_PRODUCT	AM Active Supplement Combination (Ashwagandha and Rhodiola rosea)	Ashwagandha and Rhodiola rosea
COMBINATION_PRODUCT	PM Active Supplement Combination (Magnesium threonate, L-theanine, and apigenin)	Magnesium threonate, L-theanine, and apigenin.
OTHER	AM and PM Placebo	Placebo AM and PM

Timeline

• Start date: 2025-02-15
• Primary completion: 2025-12-01
• Completion: 2026-02-01
• First posted: 2025-03-21
• Last updated: 2026-02-11

Locations

1 site across 1 country: United States