NCT06888271

DNA Methylation in Brugada Syndrome and Risk of Sudden Cardiac Death

DNA Methylation in Brugada Syndrome and Risk of Sudden Cardiac Death (ANDROMEDA)

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 10 (estimated)
• Sponsor: University of Campania Luigi Vanvitelli · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to evaluate if there are differences in DNA methylation of peripheral blood in patients with Brugada syndrome and healthy subjects. The main question it aims to answer is: Does DNA methylation changes distinguish Brugada patients from healthy controls? Does DNA methylation changes distinguish Brugada patients with high versus low risk of sudden cardiac death?

Detailed description

The Investigators will enroll 10 patients with Brugada syndrome and 10 age and sex matched healthy controls. We will collect 5 mL of peripheral blood and will analyze genome-wide DNA methylation via EPIC array platform. Bioinformatic algorithms and network analysis will be applied to identify possible diagnostic and predictive biomarkers.

Conditions

• Brugada Syndrome
• Sudden Cardiac Death Due to Cardiac Arrhythmia

Timeline

• Start date: 2025-05-01
• Primary completion: 2026-02-01
• Completion: 2026-07-01
• First posted: 2025-03-21
• Last updated: 2025-03-24