NCT06885944

Probiotics for Preterm Infants

Probiotics for Preterm Infants After Full Enteral Feeding

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Ankara City Hospital Bilkent · Academic / Other
• Sex: All
• Age: 7 Days – 3 Months
• Healthy volunteers: Not accepted

Summary

Probiotics will be used for preterm infants under 32 weeks of gestation and under 1500 g birthweight. Our aim was to investigate the effects of probiotics for stable preterm infants after extubation and who reached full enteral feeding. There are some hesitations among care-givers to start probiotics early due to safety issues although there are many positive effects of these products reported int the literature.

Detailed description

Our study included premature babies with a birth weight of less than 1500 grams, born at less than 32 weeks of gestation, and without congenital anomalies. Approval was obtained from the hospital's clinical research ethics committee before starting the study. The decision to start probiotics was made when these premature babies were fully enteral fed. The study design was created as a cohort and case-control study (No randomisation). When clinicians decided to start probiotic support for premature babies with good general health and no additional problems, probiotics were added to the baby's order.

Conditions

• Preterm Infant Feeding Outcomes
• Probiotic

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Probiotic mix preparation	Bifidobacterium containing supplement with vitamin D will start after preterm infants reaches full enteral feeding
DIETARY_SUPPLEMENT	Bifidobacteria	Rather than early period we will start probiotics after infant receive full enteral feedings

Timeline

• Start date: 2025-03-30
• Primary completion: 2025-09-30
• Completion: 2025-11-30
• First posted: 2025-03-20
• Last updated: 2025-03-20