NCT06882681

Silymarin Bioavailability Study

Novel Micellar Formulation of Silymarin with Enhanced Bioavailability in a Double-Blind, Randomized, Crossover Human Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Isura · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study seeks to evaluate and compare the pharmacokinetics of a novel micellar silymarin formulation with that of a standard silymarin formulation.

Conditions

• Bioavailability and Pharmacokinetics

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	LipoMicel Milk Thistle	A maximum single dose of approx. 140 mg silymarin (in soft gel capsule)
DIETARY_SUPPLEMENT	Unformulated Milk Thistle Extract	A maximum single dose of approx. 130 mg silymarin (in hard gel capsules)

Timeline

• Start date: 2024-05-01
• Primary completion: 2024-12-20
• Completion: 2025-01-31
• First posted: 2025-03-18
• Last updated: 2025-03-18

Locations

1 site across 1 country: Canada