NCT06882330

Neural Mechanisms of Dialectical Behavioral Therapy in Patients with Borderline Personality Disorder

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 106 (actual)
• Sponsor: Masarykova Univerzita · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Accepted

Summary

This research examines the behavioral and neural mechanisms of dialectical behavior therapy (DBT) effect in patients with borderline personality disorder (BPD).

Detailed description

This project aims to evaluate the behavioral and neural mechanisms of dialectical behavior therapy (DBT) effect in patients with borderline personality disorder (BPD). The project includes three subject groups: patients with BPD undergoing the DBT program (BPD-DBT), control patients with BPD on the waiting list for the program (BPD-control), and healthy controls (HC). Patients in the BPD-DBT group undergo a 24-week DBT program in an outpatient setting. All participants undergo a test battery comprising of self-report measures, clinical evaluation and fMRI and EEG measurement in the week before the DBT program beginning (T1), after 24 weeks (follow-up, T3), and at 24 weeks after T3 (follow-up, T4). The BPD-DBT group undergoes another assessment at T2 (after 12 weeks) to monitor selected symptoms during the DBT program by a short set of questionnaires.

Conditions

• Borderline Personality Disorder

Interventions

Type	Name	Description
BEHAVIORAL	Dialectical behavior therapy	A complex psychotherapy program for patients with borderline personality disorder.

Timeline

• Start date: 2020-08-27
• Primary completion: 2023-08-10
• Completion: 2023-08-15
• First posted: 2025-03-18
• Last updated: 2025-03-18

Locations

1 site across 1 country: Czechia