NCT06881238

Impact of Hepatitis B Virus on Inflammatory Bowel Disease

The Impact of Hepatitis B Virus Infection on the Clinical Course of Inflammatory Bowel Disease in Egyptian Patients

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 162 (estimated)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational retrospective study is to assess the impact of hepatitis B virus (HBV) infection on the clinical course and outcomes of inflammatory bowel disease (IBD) in Egyptian patients. Researchers will compare the IBD extent, location, severity, and behavior between IBD patients with and without HBV infection. Participants will be subjected to history-taking (history of hospital admission and disease flare, surgical history, medication history, follow-up duration, and mortality), clinical examination, laboratory investigations, abdominal ultrasonography, and endoscopic examination.

Conditions

• Inflammatory Bowel Disease (IBD)
• Hepatitis B Virus

Interventions

Type	Name	Description
OTHER	History of IBD course and outcome in HBV patients	Full history taking including: * Personal history (name, age, sex, occupation, residence, and marital state). * Complaint. * Age at diagnosis of IBD. * Medication history. * History of hospital admissions and disease flares. * Disease extent, location, and behavior. (Montreal classification, Truelove-Witts severity index). * Surgical history (intestinal resection in CD patients and total proctocolectomy in UC patients). * Follow up duration and mortality. * Data of endoscopic examination * Data of laboratory investigations (complete blood picture, HBV serology, liver and kidney function tests, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP)).

Timeline

• Start date: 2024-12-01
• Primary completion: 2025-05-30
• Completion: 2025-06-10
• First posted: 2025-03-18
• Last updated: 2025-03-18

Locations

1 site across 1 country: Egypt