NCT06880640

Affect-based Impulsivity in Borderline Personality Disorder

Affect-based Impulsivity in Borderline Personality Disorder: Developing a Neurocomputational Phenotype

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 106 (estimated)
• Sponsor: University of North Carolina, Chapel Hill · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research study is to investigate how personality traits and neuroendocrine systems relate to decision-making patterns in individuals 18-45 years old. The main question it aims to answer is how neuroendocrine activity impacts decision-making. Participants will complete online behavioral tasks, a stress induction procedure, self-report surveys, and a cognitive assessment. During the session, psychophysiological measures will be collected, including electrocardiogram (ECG) and cardiac impedance (ICG) to monitor heart rate and blood flow, as well as electrodermal activity (EDA), blood drop samples, and saliva collection to assess nervous system activity.

Conditions

• Borderline Personality Disorder (BPD)
• Healthy Controls Group - Age and Sex-matched

Interventions

Type	Name	Description
BEHAVIORAL	Stress Induction	Participants will complete the Trier Social Stress Test to induce stress, which includes a public speaking simulation and mental arithmetic.

Timeline

• Start date: 2025-09-21
• Primary completion: 2026-08-01
• Completion: 2026-08-01
• First posted: 2025-03-18
• Last updated: 2025-09-24

Locations

1 site across 1 country: United States