NCT06880406

Mitochondrial Function and Metabolomic Profile in Alzheimer's Disease and Related Dementias

Early Alterations of Peripheral Mitochondrial Function and Metabolomic Profile in Patients With Alzheimer's Disease and Related Dementias

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 170 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Nice · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This project aims to study on one hand the early mitochondrial alterations, common or specific, occurring in peripheral cells of patients with Alzheimer's disease or related dementia and, on the other hand, identify the metabolomic biomarkers that may be at the origin of mitochondrial disturbances associated with the disease. This will be the first study combining functional analyses of mitochondria and exploratory metabolomic assessments in the same cohort at early stages of the disease.

Detailed description

Study will be proposed to the patient of the Nice Memory center who had a lumbar puncture and who agreed on the storage of a sample of their cerebrospinal fluid. Two groups of patients will be compared: the Alzheimer"s disease patient with positive amyloid on the cerebrospinal fluid and the non Alzheimer patient with negative amyloid on the cerebrospinal fluid. Blood samples will be collected at inclusion and one year to obtain the mitochondrial metabolomic signature

Conditions

• Alzheimer Disease

Interventions

Type	Name	Description
OTHER	MMSE and blood draw	Each patient will be evaluated by Mini-Mental State Examination (MMSE) and will have a blood draw

Timeline

• Start date: 2025-07-01
• Primary completion: 2028-07-01
• Completion: 2029-04-01
• First posted: 2025-03-17
• Last updated: 2025-07-03

Locations

1 site across 1 country: France