NCT06878989

Adaptation of Human Brown Adipose Tissue to Calorie Restriction

Adaptation of Human Brown Adipose Tissue to Calorie Restriction (BATON)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Universidad de Granada · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Not accepted

Summary

The BATON study investigates how human brown adipose tissue (BAT) adapts to a controlled caloric restriction diet in young adults with obesity. A weight maintenance diet group will be compared to a group following a diet designed to induce an 8-10% weight loss over a 12-16 week period. Outcome assessments will include advanced technologies such as PET-CT and molecular analyses of BAT. The overarching goal is to gain a deeper understanding of the role of human BAT on the regulation of body weight.

Conditions

• Obesity and Overweight

Interventions

Type	Name	Description
BEHAVIORAL	Caloric restriction diet	Dietary intervention consisting on a meal plan designed to induce an 8-10% weight loss over a 12-16 week period.
BEHAVIORAL	Weight maintenance diet	Dietary intervention consisting on a meal plan designed to maintain a stable body weight for up to 16 weeks.

Timeline

• Start date: 2025-01-25
• Primary completion: 2025-12-01
• Completion: 2026-12-01
• First posted: 2025-03-17
• Last updated: 2025-12-26

Locations

1 site across 1 country: Spain