NCT06877208

The Effect of Glucagon on Cerebral Glucose Metabolism in Healthy Humans

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: Nicolai Jacob Wewer Albrechtsen · Academic / Other
• Sex: All
• Age: 55 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This is a pilot study in which the investigators will investigate the effect of exogenous glucagon on cerebral glucose metabolism in healthy humans. Participants will participate in either part C or part D of the study, and each participant will participate in three study days. During a study day the participant will receive an intravenous infusion of either glucagon, glucose (in an adjustable rate to match to glucose concentrations achieved with the glucagon infusion) or saline. During each study day an 18F-flouro-deoxy-glucose (FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) scan will be performed to quantify cerebral glucose metabolism during the first part (acute effect) of the glucagon/glucose/saline infusion (part C) or the last part (later effect) of the glucagon/glucose/saline infusion (part D).

Detailed description

Participants in this study will participate in four visits; one screening visit and three study days. Participants will be instructed to avoid strenuous exercise and alcohol intake two days prior to each experimental visit. Participants will arrive at the Department of Clinical Physiology and Nuclear Medicine after an overnight (\>10 hours) fast (including coffee and medicine). On all three study days, two peripheral venous catheters will be placed in the antecubital vein of each arm (one for the collection of blood samples and one for infusions). After two initial blood samples the infusion of either saline, glucagon or glucose will be started. The infusion rate of glucagon will be 10 ng/kg/min. The infusion rate of glucose will be adjustable, and adjusted to match the blood glucose levels achieved on the glucagon study day. During the infusion of saline, glucagon or glucose a 18F-FDG PET/CT scan will be performed. The 18F-FDG PET/CT scan will be performed either in the beginning of the infusions (approximately 15-55 min after the start of infusion) (for participants in part C) or in the end of the infusions (approximately 150-190 min after the start of infusion) (for participants in part D).

Conditions

• Cerebral Glucose Metabolism

Interventions

Type	Name	Description
OTHER	Glucagon (part C)	90 minutes intravenous infusion with glucagon (infusion rate of 10 ng/kg/min).
OTHER	Glucose clamp (part C)	90 minutes intravenous infusion of 20 % weight/volume glucose (in an ajustable rate to match the glucose levels achieved during the glucagon infusion).
OTHER	Saline (part C)	90 minutes intravenous infusion with isotonic NaCl.
OTHER	Glucagon (part D)	210 minutes intravenous infusion with glucagon (infusion rate of 10 ng/kg/min).
OTHER	Glucose clamp (part D)	210 minutes intravenous infusion of 20 % weight/volume glucose (in an ajustable rate to match the glucose levels achieved during the glucagon infusion).
OTHER	Saline (part D)	210 minutes intravenous infusion with isotonic NaCl.

Timeline

• Start date: 2025-03-01
• Primary completion: 2025-09-01
• Completion: 2026-03-01
• First posted: 2025-03-14
• Last updated: 2025-03-24

Locations

1 site across 1 country: Denmark