NCT06876870

MR-Evaluation of Renal Function in Anesthetized Pediatric Patients

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Uppsala University · Academic / Other
• Sex: All
• Age: 1 Month – 14 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to investigate the effect of the anesthetic agents sevoflurane or propofol on the blood flow and oxygen delivery to the kidneys. Pediatric patients who are planned to undergo an MRI scan with generalized anesthesia will be randomized to either IV anesthesia with propofol or inhalation anesthesia with sevoflurane. Both of these anesthetic methods are commonly used for anesthesia on an everyday basis. In addition to the clinically indicated MRI, Multiparametric MRI will be performed to visualize the effect of the anesthetic agent on renal blood flow, perfusion and oxygenation.

Detailed description

See the study protocol

Conditions

• Renal Blood Flow
• Anesthesia
• MRI
• Renal Oxygenation

Interventions

Type	Name	Description
DRUG	Anesthesia Maintenance Agent	Difference in renal blood flow (RBF) between Propofol and Sevoflurane groups. Quantified by specific Multiparametric MRI metrics (e.g., (Renal blood flow by phase contrast imaging) (regional perfusion by Arterial Spin labeling (ASL) and global and regional oxygenation by Blood oxygen dependent signal (BOLD))

Timeline

• Start date: 2025-10-01
• Primary completion: 2026-12-10
• Completion: 2027-06-20
• First posted: 2025-03-14
• Last updated: 2025-03-25