NCT06874244

Clinical Evaluation of no Needle Dental Anesthesia Compared to Syringe Anesthesia Delivery

Randomized Prospective Split Mouth Clinical Evaluation of no Needle Dental Anesthesia Compared to Syringe Anesthesia Delivery

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Louisiana State University Health Sciences Center in New Orleans · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to evaluate two different ways to administer the numbing solution. One is with a conventional needle and syringe the other method iontophoresis is a machine that supplies a weak current through electrodes that touch your teeth. Both methods use an anesthesia solution to make your teeth numb but the iontophoresis system contains no needle and the delivery device does not penetrate the gum.

Conditions

• Local Anesthesia Injection Pain

Interventions

Type	Name	Description
DRUG	Local Anesthesia (lidocaine hydrochloride)	Injection of lidocaine as local anesthesia
DRUG	Iontophoresis of Tetracaine and oxymetazoline	Injecting Tetracaine Hydrochloride 4% with 0.5% Oxymetazoline to the oral tissue using iontophoresis technique

Timeline

• Start date: 2024-08-01
• Primary completion: 2025-06-12
• Completion: 2025-07-01
• First posted: 2025-03-13
• Last updated: 2025-11-19

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study