NCT06874179

Oropharyngeal Vs Intravenous Lidocaine Effects on Optic Nerve Sheath Diameter After Intubation

Effects of Oropharyngeal-topical and Intravenous Lidocaine on the Optic Nerve Sheath Diameter Changes After Endotracheal Intubation: a Randomized Controlled Clinical Study

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 190 (estimated)
• Sponsor: Ankara City Hospital Bilkent · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the effects of pre-intubation oropharyngeal topical lidocaine on optic nerve sheath diameter (ONSD) post-endotracheal intubation. The study will measure the ONSD using ultrasonography before intubation, and at 1, 5, and 10 minutes post-intubation. The results will be compared between patients receiving %10 lidocaine topically and %2 intravenous lidocaine.

Detailed description

Increased intracranial pressure (ICP) is a critical condition that requires early and accurate assessment. Traditional invasive ICP monitoring techniques, such as lumbar puncture and intracranial pressure monitoring devices, carry significant risks. Optic nerve sheath diameter (ONSD) measurement via ultrasonography is a non-invasive method that reflects increased ICP. Patients will be divided into two groups: Group A will receive %10 topical oropharyngeal lidocaine, and Group B will receive %2 intravenous lidocaine. The primary aim of the study is to evaluate the impact of lidocaine on ONSD at 1, 5, and 10 minutes post-intubation and to compare the effects on the two groups.

Conditions

• Endotracheal Intubation During Surgery
• Optic Nerve Sheath Diameter

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Optic nerve sheath diameter measurement 0	optic nerve sheath diameter (ONSD) measured via ultrasonography before intubation
DIAGNOSTIC_TEST	optic nerve sheath diameter measurement 1	optic nerve sheath diameter measurement 1 via ultrasonography after intubation 1st minute
DIAGNOSTIC_TEST	optic nerve sheath diameter measurement 2	optic nerve sheath diameter measurement via ultrasonography after intubation 5th minute
DIAGNOSTIC_TEST	optic nerve sheath diameter measurement 3	optic nerve sheath diameter measurement via ultrasonography after intubation 10th minute
PROCEDURE	Pre-intubation oropharyngeal topical %10 lidocaine	Pre-intubation oropharyngeal topical %10 lidocaine
PROCEDURE	Pre-intubation intravenous %2 lidocaine	Pre-intubation intravenous %2 lidocaine

Timeline

• Start date: 2025-03-20
• Primary completion: 2025-11-30
• Completion: 2025-11-30
• First posted: 2025-03-13
• Last updated: 2025-03-13

Locations

1 site across 1 country: Turkey (Türkiye)