NCT06871540

Evaluation Of The Effect Of Streptococcus Salivarius K12 Probiotic In The Treatment Of Periodontitis

Evaluation Of The Effect Of Streptococcus Salivarius K12 Probiotic In The Treatment Of Periodontitis: A Randomized Controlled Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: AYŞENUR ŞAHİN · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Aims: The use of oral probiotics as an adjunct to the treatment of periodontal diseases is known to be beneficial in antagonizing pathogenic microflora and regulating the host immune response. The aim of this clinical study was to evaluate the clinical, microbiologic and biochemical effect of Streptococcus salivarius (S. salivarius) K12 probiotic tablet as an adjunct to scaling and root planing (SRP) treatment in stage 3 periodontitis patients. Methods: The study included 30 systemically healthy stage 3 periodontitis patients. After non-surgical periodontal treatment, participants were randomly assigned to the test (SRP+Probiotic, n=15) or control (SRP, n=15) group. Patients in the test group used probiotic tablets once daily for 30 days. Clinical (Plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL)), microbiological (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Prevotella intermedia, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum) and biochemical (IL-6, IL-8, IL-10) measurements were performed at baseline (before SRP), 30. and 90th days. Data were analyzed statistically. Keywords: Microbiology, Periodontitis, Probiotics, Cytokines

Conditions

• Periodontitis Stage III
• Probiotic

Interventions

Type	Name	Description
OTHER	Probiotic Agent	Patients in the test group were instructed to take one tablet immediately after tooth brushing (before bedtime) once daily for 30 consecutive days. Probiotic was administered in tablets containing 1x109 cfu/g S. salivarius K12.
OTHER	Non-Surgical Intervention	Patients in the control group received non-surgical periodontal treatment only.

Timeline

• Start date: 2023-10-01
• Primary completion: 2024-06-30
• Completion: 2024-06-30
• First posted: 2025-03-12
• Last updated: 2025-03-12

Locations

1 site across 1 country: Turkey (Türkiye)