NCT06867874

Syncytiotrophoblast-derived Extracellular Vesicles in Placenta Previa and Accreta Spectrum

Shedding of Syncytiotrophoblast-derived Extracellular Vesicles is Increased in Placenta Previa and Accreta Spectrum: a Case-control Study.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The main goal of this case-control study is to quantify the levels of circulating syncytiotrophoblast-derived extracellular vesicles (STBEVs) in maternal blood in a population of women with placenta previa and placenta accreta spectrum.

Detailed description

The main goal of this case-control study is to quantify the levels of circulating syncytiotrophoblast-derived extracellular vesicles (STBEVs) in maternal blood in a population of women with ultrasound diagnosis of PP with and without postpartum histopathologic diagnosis of PAS, compared to pregnant women with normal placentation. The secondary aim of this case-control study is to characterize the multi-omics profiling of STBEVs cargo's (proteins, gene and transcripts) isolated from patients diagnosed with PP and PAS compared to the control population.

Conditions

• Placenta Previa
• Placenta Accreta Spectrum

Interventions

Type	Name	Description
PROCEDURE	Blood sample	Blood sample

Timeline

• Start date: 2023-07-10
• Primary completion: 2025-03-01
• Completion: 2026-03-01
• First posted: 2025-03-10
• Last updated: 2025-03-10

Locations

1 site across 1 country: Italy