NCT06865300

Effects of Pretreatment With Different Doses of Lidocaine on Injection Pain

Effects of Pretreatment With Different Doses of Lidocaine on Injection Pain and Rocuronium-induced Withdrawal Response

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 210 (actual)
• Sponsor: Giresun University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

One of the medications administered to patients in general anesthesia practice is rocuronium, which causes pain during intravenous administration. It is known that a drug containing lidocaine as the active ingredient can reduce the pain caused by rocuronium in different doses. The effective dose of lidocaine remains a topic of debate. In our study, we aimed to investigate the efficacy of two different doses of lidocaine. No adverse effects are expected from this medication.

Detailed description

The patients were randomly divided into three groups by a simple drawing-lots method: control group (Group C), 40 mg lidocaine group (Group L) and 1 mg/kg lidocaine group (Group L1). All patients were taken to the operating room without premedication and standard monitoring was applied. A 20 G intravenous catheter was inserted on the dorsum of the patients' non-dominant hand, and 100 ml/hour of physiological saline solution was infused over a 5-minute period. After randomization, 5 ml of isotonic solution was administered to the control group, 40 mg of lidocaine to the L group, and 1 mg kg-1 of lidocaine intravenously to the L1 group. Patients were administered 0.06 mg/kg of rocuronium, and they were asked, "Do you feel any pain or discomfort in your arm?" The pain intensity expressed by the patient was evaluated and recorded using the 5-point pain scale. After induction and intubation, the patients' blood pressure, pulse, and saturation values were recorded.

Conditions

• Rocuronium Adverse Reaction
• Lidocaine Adverse Reaction

Interventions

Type	Name	Description
DRUG	Lidocain 40 mg	We injected 40 mg lidocain before rocuronium injection. Then we recorded pain score by using visual analog scale.
DRUG	lidocain 1 mg/kg	We injected 1 mg/kg lidocain before rocuronium injection. Then we recorded pain score by using visual analog scale.
DRUG	serum physiologic	We injected serum physiologic before rocuronium injection. Then we recorded pain score by using visual analog scale.

Timeline

• Start date: 2023-07-01
• Primary completion: 2023-10-31
• Completion: 2023-12-31
• First posted: 2025-03-07
• Last updated: 2025-03-07

Locations

2 sites across 1 country: Turkey (Türkiye)