NCT06864416

Comparative Study Between Dexmedetomidine and Fentanyl as Adjuvants to Bupivacaine

Comparative Study Between Dexmedetomidine and Fentanyl as Adjuvants to Bupivacaine in Femero Sciatic Block for Below Knee Surgery

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Combined femoral and sciatic nerve block provides surgical anesthesia with better cardiorespiratory stability as compared to the spinal anesthesia blockade which has side effects of hypotension, bradycardia, meningitis, post dural puncture headache, hematoma, and neurological deficit

Detailed description

Combined femoral and sciatic nerve block provides surgical anesthesia with better cardiorespiratory stability as compared to the spinal anesthesia blockade which has side effects of hypotension, bradycardia, meningitis, post dural puncture headache, hematoma, and neurological deficit, Adjuvants are those drugs which, when co-administered with local anesthetic agents, may improve the speed of onset and duration of analgesia and counteract disadvantageous effects of local anesthetics. By adding these adjuvants, the dose of local anesthetics like bupivacaine can be reduced, thereby reducing its side effects like myocardial depression, hypotension, bradycardia, heart block, and ventricular arrhythmias. Based on "Combination Wisdom", the use of adjuvants to local anesthetics has been promoted a lot .A wide variety of drugs have been used for both neuraxial and peripheral nerve blocks, and the most commonly used drug as adjuvant is the fentanyl . The addition of dexmedetomidine during US-guided combined femoral and sciatic block for below knee surgery was associated with a prolonged duration of analgesia.

Conditions

• Post Operative Pain

Interventions

Type	Name	Description
DRUG	dexmedetomidine as adjuvant to bupivacaine	the efficacy of addition of dexmedetomidine as adjuvants to bupivacaine in femorosciatic nerve block
DRUG	Fentanyl as adjuvant to bupivacaine	the efficacy of addition of fentanyl as adjuvants to bupivacaine in femorosciatic nerve block

Timeline

• Start date: 2024-03-11
• Primary completion: 2024-10-01
• Completion: 2024-11-01
• First posted: 2025-03-07
• Last updated: 2025-03-07

Locations

1 site across 1 country: Egypt