Trials / Completed
CompletedNCT06864104
A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension (KARDINAL)
A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Monthly Subcutaneous Administration of Tonlamarsen in Participants With Uncontrolled Hypertension (KARDINAL)
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 206 (actual)
- Sponsor
- Kardigan, Inc. · Industry
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to evaluate the blood pressure (BP)-lowering efficacy of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Tonlamarsen | Tonlamarsen will be administered subcutaneously (SC) every 4 weeks during the randomized part of the study |
| DRUG | Placebo | Placebo will be administered subcutaneously (SC) every 4 weeks during the randomized part of the study |
Timeline
- Start date
- 2025-04-10
- Primary completion
- 2026-01-12
- Completion
- 2026-03-17
- First posted
- 2025-03-07
- Last updated
- 2026-03-31
Locations
39 sites across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT06864104. Inclusion in this directory is not an endorsement.