NCT06861140

Exploring the Influence of Trptophan on the Treatment of Pouchitis

Untersuchung Des Einflusses Einer Tryptophanreichen Diät Auf Das Therapeutische Potential Von Probiotika Nach Antibiotischer Therapie Bei Chronischer Pouchitis (Try Pro Pouch). Eine Prospektive Randomisierte Kontrollierte Doppelblinde Interventionsstudie

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Universitätsklinikum Hamburg-Eppendorf · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients with a pouch frequently suffer from chronic inflammation of the intestinal tract, called pouchitis. Pouchitis is routienly treated with repeated courses of antibiotics and probiotics, which does not stop the inflammation from recurring and exposes the patients to the risk of developing antibiotic -resistant pouchitis. Experimental data suggest that the effectiveness of the antibiotic and probiotic treatment can be prolonged by high consumption of trypotophan, an aminoacid present in everyday food. The Try Pro Pouch study aims to compare the consumption of high amounts of tryptophan against placebo in patients with pouchitis.

Detailed description

Participants with chronic pouchitis receive either a weight adapted supplement containing etiher trypotophan or a placebo after completing the standard treatment with antibiotics or probiotics for their pouchitis. Endoskopy will be performed, stool and blood will be sampled, symptoms will be monitored.

Conditions

• Pouchitis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Tryptophan 25mg/kg bodyweight	Tryptophan is supplemented during the treatment of chronic pouchitis with pro- and antibiotics
OTHER	Placebo	standard treatment of chronic pouchitis using pro- and antibiotics.

Timeline

• Start date: 2025-04-01
• Primary completion: 2027-04-30
• Completion: 2027-04-30
• First posted: 2025-03-06
• Last updated: 2025-03-06