NCT06859723

High Potency Cannabis: Acute and Protracted Effects

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 21 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research is to assess the effects of smoked cananbis when cannabis is smoked during periods of cannabis use as usual and after a brief period of abstinence.

Detailed description

This outpatient study will assess the acute pharmacodynamic effects of smoked cannabis with \~50 mg and \~100 mg THC compared to placebo (\~0 mg THC) and whether a brief period of abstinence alters these effects. Metabolism (pharmacokinetics) of THC will be examined to associate behavioral and physiological effects to plasma concentrations of THC and metabolites.

Conditions

• Abuse Cannabis
• Pain
• Pharmacokinetics

Interventions

Type	Name	Description
DRUG	Placebo Comparator: Placebo	Placebo
DRUG	Low dose THC	Smoked low dose THC
DRUG	High dose THC	Smoked high dose THC

Timeline

• Start date: 2025-07-03
• Primary completion: 2027-07-01
• Completion: 2028-07-01
• First posted: 2025-03-05
• Last updated: 2025-10-06

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study