NCT06859307

Intra-Abdominal Instillation Of Fresh Frozen Plasma Versus Corticosteroids In Prevention Of Recurrent Attacks Of Adhesive Intestinal Obstruction: A 2 Years' Experience Clinical Study

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 176 (estimated)
• Sponsor: Zagazig University · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Adhesive Intestinal obstruction is an inevitable complication of abdominal surgery with significant morbidity associated with poor quality of life and predispose to repeated hospitalization. Most of them (73% - 90%) can be managed conservatively.Despite advances in surgery, 15to 30% require surgical intervention primarily or due to failure of conservative management. Because of the nature of the disease recurrence has been estimated to be 30%.Many attempts to prevent formation of postoperative adhesions have been tried. In this trial, we will study the effect of corticosteroids and FFP in prevention of adhesive small bowel obstruction recurrence for follow up of 2 years duration.

Conditions

• Adhesive Peritoneal Band

Interventions

Type	Name	Description
PROCEDURE	intra-abdominal instillation of corticosteroids	after adhesiolysis, peritoneal lavage with diluted corticosteroids will be instillated intra-abdominally
PROCEDURE	intra-abdominal instillation of fresh frozen plasma	after adhesiolysis, peritoneal lavage with diluted FFP will be instillated intra-abdominally

Timeline

• Start date: 2025-03-01
• Primary completion: 2027-03-01
• Completion: 2027-03-01
• First posted: 2025-03-05
• Last updated: 2025-08-14

Locations

2 sites across 1 country: Egypt