NCT06856434

Effect of Probiotic's Consumption on Several Markers in Perforated Appendix Patients With Diffuse Peritonitis

Effect of Lactobacillus Plantarum Probiotics on Inflammation and Postoperative Complications in Patients With Diffuse Peritonitis Due to Perforated Appendicitis After Laparotomy Appendectomy: A Randomized Controlled Trial

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Universitas Padjadjaran · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Does the administration of the probiotic Lactobacillus plantarum sp. have an impact on reducing leukocyte levels, segmented neutrophil counts, postoperative pain, and length of hospitalization in patients with diffuse peritonitis caused by perforated acute appendicitis who underwent laparotomy appendectomy at Dr. Hasan Sadikin Hospital?

Detailed description

To determine whether the administration of the probiotic Lactobacillus plantarum sp. to patients with diffuse peritonitis caused by appendiceal perforation undergoing laparotomy appendectomy at Hasan Sadikin Hospital Bandung and Siloam Karawaci Hospital has a significant effect on leukocyte levels, segmented neutrophil counts, postoperative pain levels, and length of hospitalization compared to the placebo group.

Conditions

• Appendicitis With Perforation
• Appendectomy
• Probiotic

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Lactobacillus plantarum sp Probiotic	Once daily consumption
OTHER	Placebo Group	Group who received a placebo intervention

Timeline

• Start date: 2025-08-01
• Primary completion: 2026-08-01
• Completion: 2026-09-30
• First posted: 2025-03-04
• Last updated: 2026-03-31

Locations

1 site across 1 country: Indonesia