NCT06854432

Assessment of Biological and Biometrological Parameters in Adult Subjects with Androgenetic Alopecia

Multi-omics Approaches and Biometrological Analyses to Better Understand Androgenetic Alopecia: Exploratory Study

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 46 (actual)
• Sponsor: Pierre Fabre Dermo Cosmetique · Industry
• Sex: Male
• Age: 30 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Androgenetic alopecia is a chronic pathology affecting approximately 50% of men at 50 years old and is characterized by a progressive miniaturization of the hair follicle leading to a localized baldness. Although it has been shown that testosterone metabolism plays a central role in this pathology, targeting this biological pathway is not fully efficient to treat androgenetic alopecia, suggesting that other factors are involved, notably factors linked to the perifollicular environment. Moreover, the very specific pattern of androgenetic alopecia is not yet fully understood: the occipital and lower temporal areas of the scalp are always preserved. Once the hair follicle has disappeared, it is not possible to make it grow back, it is then important to provide a treatment that slows down the progression of androgenetic alopecia at the earliest stage of the pathology, and that specifically targets the affected area. The aim of this study is to better understand androgenetic alopecia pathophysiology by a multi-omic approaches and biometrological analysis, in the same study, on the local ecosystem of bald scalp areas and non-bald scalp areas of adult with androgenetic alopecia, compared to scalp of adult without androgenetic alopecia.

Conditions

• Alopecia, Androgenetic
• Healthy

Interventions

Type	Name	Description
OTHER	Biometrological measurements	Measurements will be taken from the scalp: on the vertex and occiput areas.
OTHER	Biological sampling	Samples will be taken from the scalp: on the vertex and occiput areas.

Timeline

• Start date: 2024-03-05
• Primary completion: 2024-04-25
• Completion: 2024-04-25
• First posted: 2025-03-03
• Last updated: 2025-03-03

Locations

1 site across 1 country: France