Trials / Completed
CompletedNCT06854406
A Study of Varenicline in the Treatment of Visceral Sensation
Varenicline in the Treatment of Visceral Sensation: A Pilot Study
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 8 (actual)
- Sponsor
- Mayo Clinic · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to evaluate the effect of varenicline on rectal sensation, based on ascending method of limits and on graded rapid phasic distensions in participants with non-constipation IBS and chronic abdominal pain.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Varenicline | Initial, 0.5 mg orally once daily for 3 days, then 0.5 mg every 12 hours on days 4 through 7, and then 1 mg in morning of day 8. Medication is taken after eating and with a full glass of water. |
Timeline
- Start date
- 2025-06-01
- Primary completion
- 2025-11-30
- Completion
- 2025-12-31
- First posted
- 2025-03-03
- Last updated
- 2026-01-06
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT06854406. Inclusion in this directory is not an endorsement.