NCT06850064

Efficacy and Safety of Pulsed Field Ablation in Refractory Mitral Isthmus-dependent Atrial Flutter: Pulsed Field Ablation Vs. Radiofrequency Ablation: a Preliminary Randomized Controlled Study

Efficacy and Safety of Pulsed Field Ablation in Refractory Bisththis-dependent Atrial Flutter: Pulsed Field Ablation Vs. Radiofrequency Ablation: a Preliminary Randomized Controlled Study

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Shanghai Chest Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Efficacy and safety of pulsed field ablation in refractory mitral isthmus-dependent atrial flutter: pulsed field ablation vs. radiofrequency ablation: a preliminary randomized controlled study

Detailed description

This study aims to compare the effectiveness of pulse field ablation (PFA) versus radiofrequency ablation (RFCA) in improving mitral valve commissural block rate and atrial tachycardia recurrence rate in patients with refractory mitral valve commissural-dependent atrial flutter. Study Design: Randomized Groups: Patients will be randomly assigned to two groups: Pulse Field Ablation (PFA) Group Radiofrequency Ablation (RFCA) Group

Conditions

• Atrial Fibrillation (AF)

Interventions

Type	Name	Description
PROCEDURE	Pulse Field Ablation (PFA)	The pulse field ablation group will undergo pulse field ablation of the mitral valve commissure.
PROCEDURE	Radiofrequency ablation	In the radiofrequency ablation group, patients will undergo radiofrequency ablation targeted at the mitral valve commissure.

Timeline

• Start date: 2025-02-24
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2025-02-27
• Last updated: 2025-02-27

Locations

1 site across 1 country: China