NCT06848881

Cryoablation vs Thoracoscopic Surgery for GGN

Cryoablation Versus Thoracoscopic Surgery for Pulmonary Ground-Glass Nodules: A Prospective, Comparative, Open Label Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 160 (estimated)
• Sponsor: Shanghai Chest Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to investigate the efficacy and safety of Cryoablation and Thoracoscopic Surgery in the treatment of pulmonary ground-glass nodules.

Detailed description

The primary treatment for GGN type lung cancer is surgical resection, typically using video-assisted thoracoscopic surgery (VATS). Image-guided ablation therapy is considered as a treatment option for early-stage lung cancer patients unsuitable for surgery. It has been recommended by several guidelines as one of the curative treatment methods for primary lung cancer. Among various ablation techniques, cryoablation has the lowest complication rate. However, there is currently no research exploring whether cryoablation is not inferior to thoracoscopic surgery in terms of safety and efficacy in treating highly suspected malignant lung GGNs. This study is designed as a prospective, non-randomized study, with 160 patients expected to be enrolled, who will be assigned to cryoablation or video-assisted thoracoscopic surgery treatment groups based on patient preference. The primary endpoint is the 2-year disease-free survival. Secondary endpoints include 1-month mortality rate, overall survival, 5-year disease-free survival, local recurrence rate, VATS/ cryoablation completion rate, safety, etc.

Conditions

• Ground-Glass Opacity

Interventions

Type	Name	Description
PROCEDURE	Cryoablation	The eligible patient will be voluntarily assigned to the cryoablation group and receive cryoablation.
PROCEDURE	Thoracoscopic Surgery	The eligible patient will be voluntarily assigned to thoracoscopic surgery group and receive surgery.

Timeline

• Start date: 2025-04-20
• Primary completion: 2030-04-15
• Completion: 2030-04-15
• First posted: 2025-02-27
• Last updated: 2026-03-20

Locations

1 site across 1 country: China