NCT06848595

Mg Sulfate Versus Dexmedetomidine on Cerebral Oxygen Saturation

Effects of Dexmedetomidine Versus Magnesium Sulfate on Cerebral Oxygen Saturation During Spine Surgery: a Prospective Randomized Controlled Study

• Status: Not Yet Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 21 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This study is to evaluate the effects of dexmedetomidine and magnesium sulfate on cerebral oxygen saturation in patients undergoing spine surgeries as adjuvant to general anesthesia guided by cerebral oximetry. The main aims to are Incidence of cerebral desaturation events and duration of cerebral desaturation events.

Conditions

• Cerebral Desaturation Events
• Spine Surgeries

Interventions

Type	Name	Description
PROCEDURE	spine surgery	spine surgery in prone position
DRUG	Magnesium sulfate	Patients will receive loading dose of 40 mg/kg of magnesium sulfate diluted in 50 ml of 0.9% saline IVI will be given in 10 min before anesthesia induction then continuous infusion of 10 mg/kg/hour during the surgery.
DRUG	Dexmedetomidine	Patients will receive loading dose of 1 mcg/kg dexmedetomidine diluted in 50 ml of saline 0.9% IVI will be given in 10 min before anesthesia induction then continuous infusion of 0.5 mcg/kg/hour during the surgery.
DRUG	Normal Saline (0.9% NaCl)	Patients will receive the same volume of normal saline.

Timeline

• Start date: 2025-02-23
• Primary completion: 2027-01-20
• Completion: 2027-01-31
• First posted: 2025-02-27
• Last updated: 2025-02-27