NCT06848530

Neurophysiology of the Basal Ganglia, Thalamus, and Cerebellum in Patients With Movement Disorders

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The research study is being conducted to better understand parts of the human brain called the cortex, basal ganglia, thalamus, and cerebellum in patients with movement disorders (such as Parkinson's disease, essential tremor, dystonia, or ataxia). These brain structures are involved in movement disorders. This study attempts to better understand the brain electrical activity associated with these disorders, both in patients with and without deep brain stimulation (DBS). Recordings are made from the scalp with a noninvasive electrode and/or through the DBS stimulator if the participant has a stimulator model that is able to sense brain activity. These recordings are analyzed along with measures of movement disorder symptoms to identify brain signal signatures of symptoms.

Conditions

• Movement Disorders

Interventions

Type	Name	Description
OTHER	Prescribed Medications	participant's movement disorders medications, prescribed by their treating physician
OTHER	Deep brain stimulation adjustment	Deep brain stimulator parameters may be adjusted within normal clinical limits

Timeline

• Start date: 2025-12-10
• Primary completion: 2030-04-01
• Completion: 2030-04-01
• First posted: 2025-02-27
• Last updated: 2026-03-11

Locations

1 site across 1 country: United States