NCT06848387

Unbound Cloxacillin Concentrations During Continuous Infusion

Concentration of Unbound Cloxacillin in Adults Treated With Continuous Infusion Via Elastomeric Pump

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 25 (estimated)
• Sponsor: Emeli Månsson · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Cloxacillin is the first-line choice for the treatment of severe infections caused by the bacterium Staphylococcus aureus in Sweden. Over the past year, cloxacillin is increasingly administred through continuous infusion. In this study, the free (unbound) concentration of cloxacillin when administered as a continuous infusion will be measured to ensure that the free concentration is neither too high nor too low. A PK/PD model will be developed to predict which dosage of cloxacillin is appropriate for an individual based on age, gender, kidney function, and serum-protein level.

Conditions

• Staphylococcal Infections

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Unbound cloxacillin concentration	Unbound cloxacillin concentration measured at baseline, after 4h, after 24h and after 48h of continuous infusion.

Timeline

• Start date: 2026-01-14
• Primary completion: 2026-12-01
• Completion: 2027-12-01
• First posted: 2025-02-27
• Last updated: 2026-02-17

Locations

1 site across 1 country: Sweden