Trials / Active Not Recruiting
Active Not RecruitingNCT06844864
Adaptive and Trained Immunity in the Pathogenesis of IgG4-Related Disease
Identification of Adaptive and Trained Immune Mechanisms Driving Tissue Fibrosis in IgG4-Related Disease
- Status
- Active Not Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 20 (estimated)
- Sponsor
- IRCCS San Raffaele · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
Enquire involvement of trained immunity in the pathogenesis of IgG4RD
Detailed description
Enquire involvement of trained immunity in the pathogenesis of IgG4RD using primary macrophages and co-cultures with patient derived fibroblasts. The investigators will first assess whether macrophages from patients are trained compared to macrophages of healthy controls and then challenge them with IgG from IgG4RD patients to evaluate the functional effects on cultivated fibroblasts.
Conditions
Timeline
- Start date
- 2025-03-01
- Primary completion
- 2025-09-01
- Completion
- 2025-09-01
- First posted
- 2025-02-25
- Last updated
- 2025-04-30
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT06844864. Inclusion in this directory is not an endorsement.