NCT06844032

Predictors of Poor Prognosis in HFpEF

Clinical, Hemodynamic and Neurohumoral Predictors of Poor Prognosis in Heart Failure With Preserved Ejection Fraction

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation · Other Government
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

Patients with HFpEF who have undergone meticulous clinical and instrumental evaluation (including diastolic exercise testing) between 2013 and 2020, will be followed up for at least 3 years.

Detailed description

Heart failure with preserved ejection fraction (HFpEF) is a serious condition with an unfavorable prognosis. The investigators aimed to evaluate in patients with HFpEF: * the prognostic significance of standard resting hemodynamic parameters compared to key cardiac reserves; * the prognostic significance of clinical parameters (sex, age, NYHA class, extra-cardiac diseases, therapy); * the prognostic significance of biological markers of hemodynamic stress and biomarkers of inflammation and fibrosis; * to identify independent predictors of adverse prognosis of HFpEF.

Conditions

• HFpEF

Timeline

• Start date: 2022-01-31
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2025-02-25
• Last updated: 2026-04-17

Locations

1 site across 1 country: Russia