NCT06843824

A Graphene Far-infrared Intervention Study of Cognitive Status in Older Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 126 (actual)
• Sponsor: Institute of Psychology, Chinese Academy of Sciences · Academic / Other
• Sex: All
• Age: 45 Years
• Healthy volunteers: Accepted

Summary

This study is a 4-week group controlled trial to explore whether graphene far-infrared intervention can improve the cognitive status of older adults presenting with symptoms of Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), or Alzheimer's Disease (AD), and is dedicated to enhancing the cognitive status of older adults and improving their mental health. Participants were older adults who presented with cognitive problems. Participants were divided into SCD and MCI/AD groups based on their cognitive level, and each group was further divided into a graphene far-infrared intervention group and a placebo control group. We also measured the depression and anxiety levels of the older adults and incidentally observed whether the graphene far-infrared intervention could have a positive impact on their mental health outcomes, which was not the focus of our study.

Conditions

• Mild Cognitive Impairment (MCI)
• Subjective Cognitive Decrease (SCD)
• Alzheimer's Disease(AD)
• Depression/Anxiety Symptoms

Interventions

Type	Name	Description
DEVICE	a custom-made graphene therapy cap	The GFII involved the use of a custom-made graphene therapy cap. The cap consisted of 3 parts: the main body of the cap, the thermostat and the power adapter. One end of the thermostat was connected to the main body of the cap, and the other end was connected to the power adapter; the adapter was plugged into a 220 V household power outlet. This turned on the cap, and the temperature could be adjusted. The light energy conversion rate of the graphene coating material used in the cap reached 90%, generating a temperature of 40 °C. Five caregivers were responsible for providing care for the elderly individuals. We will provided standardized training on the GFII to their caregivers. Each caregiver was responsible for assisting with the intervention of the elderly individuals that they usually cared for.
DEVICE	A regular cap that generates heat	The rest of the procedure is the same as the GFII group, but the cap used is a regular cap that can heat up to 40°C.

Timeline

• Start date: 2025-03-10
• Primary completion: 2025-05-11
• Completion: 2025-05-30
• First posted: 2025-02-25
• Last updated: 2026-03-25

Locations

1 site across 1 country: China