NCT06842433

The NUTRIOME Study - a Data-driven Precision Nutrition Intervention

The NUTRIOME Meal Study - a Data-driven Precision Nutrition Intervention Study Using Meal Responses

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Chalmers University of Technology · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The overall objective of this multi-center study is to use metabolic response data from different dietary challenges to develop personalized dietary advice. Effectiveness of this personalized dietary advice compared to a general healthy diet based on national dietary guidelines on markers of cardio-metabolic health will be tested. A total of 120 men and women who meet all inclusion criteria and none of the exclusion criteria will be invited to participate. The study will be conducted at three sites: Chalmers University of Technology (Sweden), University of Wageningen (Netherlands), and University of Oslo (Norway), with 40 participants per site.The study is conducted in two parts. The first part, the characterization phase, is a three-way randomized, controlled cross-over design, featuring one-day meal tests with isocaloric meals containing different carbohydrate, fat and protein quantity as well as quality. Based on the metabolic response to the meal tests a personalized diet will be constructed. In the second part, the main intervention, effectiveness of this personalized dietary advice compared to a general healthy diet will be tested in a six week parallel group intervention study.

Conditions

• Metabolic Control

Interventions

Type	Name	Description
OTHER	General healthy diet	General healthy diet based on national health dietary guidelines.
OTHER	Personalized diet	Personalized diet will be based on an algorithm considering the individuals' postprandial glucose, triglycerides and inflammation markers to each of the three study meals in the characterization phase (Phase I) matched with established knowledge about the effects of specific foods on such metabolic parameters.

Timeline

• Start date: 2025-03-14
• Primary completion: 2026-06-30
• Completion: 2026-06-30
• First posted: 2025-02-24
• Last updated: 2025-03-21

Locations

3 sites across 3 countries: Netherlands, Norway, Sweden