NCT06840327

Impact of VARIation of OXYdo-reduction Potential in Cardiac Surgery on Post-operative Outcome

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 120 (estimated)
• Sponsor: University Hospital, Toulouse · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Observational, prospective, monocentric study conducted in the cardiac surgery department about biological markers to predict the short-term outcome of heart surgery patients.

Detailed description

At present, there are no biological markers to predict the short-term outcome of heart surgery patients. Redox balance, determined by the interaction between oxidants and reducers in tissues, is an essential parameter in the regulation of cellular functions. Cardiac surgery with extracorporeal circulation (CEC) induces major disturbances in this balance. In preliminary work, it was observed that the redox potential (Eg) varied with the introduction of CEC, and a persistent imbalance appeared to correlate with post-operative complications. It is believed that Eg potential could be a new biomarker of the post-operative outcome of major surgery.

Conditions

• Cardiac Surgery
• Extracorporeal Circulation

Interventions

Type	Name	Description
OTHER	Blood and tissue samples	Blood samples will be taken from catheters placed for the purpose of surgery (arterial and venous catheters), or during routine venipunctures. (D-1 pre-op). Tissue samples will be taken from surgical waste generated by the surgery. They will therefore not require any additional incisions or surgical procedures.
OTHER	walking test	The study includes a walking test between D5 and D7.

Timeline

• Start date: 2025-03-01
• Primary completion: 2027-06-01
• Completion: 2027-06-01
• First posted: 2025-02-21
• Last updated: 2025-02-21