NCT06838923

Effects of Light vs. Heavy Paraffin Oil on Embryo Culture in IVF: A Prospective Study on Development and Pregnancy Rate

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 818 (actual)
• Sponsor: Hung Vuong Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This prospective study aims to compare the effects of light and heavy paraffin oil in embryo culture during in vitro fertilization (IVF). Paraffin oil is commonly used in IVF laboratories to protect embryo culture media from evaporation and temperature fluctuations. However, the impact of different oil viscosities on embryo development and pregnancy outcomes remains unclear. Participants undergoing IVF treatment will have their embryos cultured under either light or heavy paraffin oil conditions. The study will evaluate key outcomes, including embryo development, blastocyst formation rates, and pregnancy rates. Findings from this research may help optimize embryo culture conditions, potentially improving IVF success rates and guiding best laboratory practices.

Conditions

• Embryo Development
• Blastocyst IVF
• Pregnancy Rates
• IVF
• Embryo Culture Media

Interventions

Type	Name	Description
COMBINATION_PRODUCT	Light Paraffin Oil	Embryos in this group will be cultured under conditions using light paraffin oil as an overlay in in vitro fertilization (IVF). The oil serves to protect the culture media from evaporation and temperature fluctuations. Key outcomes, including embryo development, blastocyst formation rate, and pregnancy rate, will be assessed.
COMBINATION_PRODUCT	Heavy Paraffin Oil	Embryos in this group will be cultured under conditions using heavy paraffin oil as an overlay in in vitro fertilization (IVF). This study aims to compare the effects of heavy paraffin oil to light paraffin oil in embryo culture, assessing embryo development, blastocyst formation, and pregnancy rates.

Timeline

• Start date: 2023-05-23
• Primary completion: 2023-12-31
• Completion: 2025-01-15
• First posted: 2025-02-21
• Last updated: 2025-02-21

Locations

1 site across 1 country: Vietnam