NCT06835816

Amino Acid Supplementation in Continuous Renal Replacement Therapy

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Karolinska University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

ICU patients treated with continuous renal replacement therapy is recruited prior to start of treatment. Blood samples are drawn and then dialysis start without amino acid supplementation. After a few hours samples are drawn from blood and dialysate. Then patients are given amino acid supplementation (33.5g/24hrs) for 20-24 hours. New samples are drawn and amino acid supplementation is increased to 67g/24hrs and new samples are drawn after additional 24 hours. Then CRRT will continue with the full amino acid supplementation (standars of care).

Conditions

• Acute Kidney Injury

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Amino acid supplementation (Glavamin, Fresenius Kabi)	Mixture of amino acids (67 g / 500 ml) given intravenously

Timeline

• Start date: 2025-02-03
• Primary completion: 2026-12-31
• Completion: 2028-12-31
• First posted: 2025-02-19
• Last updated: 2025-02-19

Locations

1 site across 1 country: Sweden