NCT06835335

Opioid Prescribing in the Emergency Department for Sickle Cell Disease

Differential Opioid Prescribing in the Emergency Department for Patients With Sickle Cell Disease: a Vignette-based International Randomised Trial.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,063 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nīmes · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This study consists of a clinical vignette presented to emergency physicians asking them what they would prescribe to a patient with acute abdominal pain.

Conditions

• Discrimination, Racial
• Pain Management
• Emergency Medicine
• Sickle Cell Disease

Interventions

Type	Name	Description
BEHAVIORAL	opioid prescription	The intervention consisted of a randomized questionnaire presenting a clinical case of a patient suffering from severe abdominal pain. The control case was "As an emergency physician in an adult emergency department, you are presented with the following patient: The patient is a 39-year-old non-smoking male/female with a history of Meniere's disease and an allergy to Bactrim. He/she presents with abdominal pain that began abruptly 2 hours ago and has persisted despite taking NEFOPAM 45 minutes ago. This is his first episode. His/her vital signs are blood pressure 140/66, heart rate 91, pulse ox 97%, temperature 36.8°C. He/she rates his/her pain as 8/10 without any analgesic position. On clinical examination he/she presents with localized epigastric tenderness. The rest of the abdomen is soft, painless and depressed. There are hydro-aeriform noises. No diarrhea or vomiting. The rest of the clinical examination showed no abnormalities.". In the intervention case, patient had history of S

Timeline

• Start date: 2025-02-17
• Primary completion: 2025-03-19
• Completion: 2025-03-19
• First posted: 2025-02-19
• Last updated: 2026-01-23

Locations

2 sites across 2 countries: France, United Kingdom